SLActive® 1 Straumann SLActive implants compared to Straumann SLA implants.Lang NP, Salvi GE, Huynh-Ba G, Ivanovski S, Donos N, Bosshardt DD.Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans.Clin Oral Implants Res.2011 Apr;22（4）:349-56. doi: 10.1111/j.1600-0501.2011.02172.x.2 Rupp F, Scheideler L, Olshanska N, de Wild M, Wieland M, Geis-Gerstorfer J. Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces.Journal of Biomedical Materials Research A, 76(2):323-334, 2006. 3 De Wild M. Superhydrophilic SLActive® implants.Straumann document 151.52, 2005; Katharina Maniura.Laboratory for Materials – Biology Interactions Empa, St. Gallen, Switzerland, Protein and blood adsorption on Ti and TiZr implants as a model for osseointegration.EAO 22nd Annual Scientific Meeting, October 17 – 19 2013, Dublin.Kopf BS, Schipanski A, Rottmar M, Berner S, Maniura-Weber K, Enhanced differentiation of human osteoblasts on Ti surfaces pre-treated with human whole blood.Acta Biomaterialia.2015 June; 19: 180–190. Kopf BS, Ruch S, Berner S, Spencer ND, Maniura-Weber K, The role of nanostructures and hydrophilicity in osseointegration: In-vitro protein-adsorption and blood-interaction studies.J Biomed Mater Res A. 2015 August; 103 (8): 2661-2672. 4 Schwarz, F., et al., Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive®) and conventional SLA® titanium implants: an immunohistochemical study in dogs.J Clin.Periodontol.35.1 (2008): 64-75.5 Rausch-fan X, Qu Z, Wieland M, Matejka M, Schedle A. Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces.Dental Materials 2008 Jan;24(1):102-10.Epub 2007 Apr 27.6 Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA® titanium implants: Preliminary results of a pilot study in dogs.Clinical Oral Implants Research, 11(4): 481-488, 2007.7 Raghavendra S, Wood MC, Taylor TD.Int. J. Oral Maxillofac.Implants.2005 May–Jun;20(3):425–31.9.8 Oates TW, Valderrama P, Bischof M, Nedir R, Jones A, Simpson J, Toutenburg H, Cochran DL.Enhanced implant stability with a chemically modified SLA® surface: a randomized pilot study.Int. J. Oral Maxillofac.Implants.2007;22(5):755–760.9 Nicolau P, Guerra F, Reis R, Krafft T, Benz K , Jackowski J 10-year results from a randomized controlled multicenter study with immediately and early loaded SLActive implants in posterior jaws.Presented at 25th Annual Scientific Meeting of the European Association of Osseointegration – 29 Sep – 1 Oct 2016, Paris.10 Nelson, K., Stricker, A., Raguse, J.-D. and Nahles, S. (2016), Rehabilitation of irradiated patients with chemically modified and conventional SLA implants: a clinical clarification.J Oral Rehabil, 43: 871–872. doi:10.1111/joor.12434.11 Patients treated with dental implants after surgery and radio-chemotherapy of oral cancer.Heberer S, Kilic S, Hossamo J, Raguse J-D, Nelson K. Rehabilitation of irradiated patients with modified and conventional sandblasted, acid-etched implants: preliminary results of a split-mouth study.Clin.Oral Impl.Res.22, 2011; 546–551.12 Straumann (2016).SLActive® supports enhanced bone formation in a minipig surgical GBR model with coronal circumferential defects.Unpublished data. SLA® 13 Buser D, Janner SF, Wittneben JG, Bragger U, Ramseier CA, Salvi GE.10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients.Clin Implant Dent Relat Res.2012 Dec;14(6):839-51.14 Fischer K, Stenberg T.: Prospective 10-year cohort study based on a randomized controlled trial (RCT) on implant-supported full-arch maxillary prostheses.Part 1: sandblasted and acid-etched implants and mucosal tissue.Clin Implant Dent Relat Res.2012 Dec;14(6):808-15.15 van Velzen FJ, Ofec R, Schulten EA, Ten Bruggenkate CM,.10-year survival rate and the incidence of peri-implant disease of 374 titanium dental implants with a SLA surface: a prospective cohort study in 177 fully and partially edentulous patients.Clin Oral Implants Res.2015 Oct;26(10):1121-8.16 Cochran DL, Jackson JM, Bernard JP, ten Bruggenkate CM, Buser D, Taylor TD, Weingart D, Schoolfield JD, Jones AA, Oates TW Jr. A 5-year prospective multicenter study of early loaded titanium implants with a sandblasted and acid-etched surface.Int J Oral Maxillofac Implants.2011 Nov-Dec;26(6):1324-32.17 Cochran D, Oates T, Morton D, Jones A, Buser D, Peters F. Clinical field trial examining an implant with a sand-blasted, acid-etched surface.J Periodontol.2007 Jun;78(6):974-82.18 Bornstein MM, Schmid B, Belser UC, Lussi A, Buser D. Early loading of non-submerged titanium implants with a sandblasted and acid-etched surface.5-year results of a prospective study in partially edentulous patients.Clin Oral Implants Res.2005 Dec;16(6):631-8.19 Roccuzzo M1, Aglietta M, Bunino M, Bonino L. Early loading of sandblasted and acid-etched implants: a randomized-controlled double-blind split-mouth study.Five-year results.Clin Oral Implants Res.2008 Feb;19(2):148-52.20 Derks J, Schaller D, Håkansson J, Wennström JL, Tomasi C, Berglundh T. Effectiveness of Implant Therapy Analyzed in a Swedish Population: Prevalence of Peri-implantitis.J Dent Res.2016 Jan;95(1):43-9. doi ZLA® 21 Bormann KH, Gellrich NC, Kniha H, Dard M, Wieland M, Gahlert M. Biomechanical evaluation of a microstructured zirconia implant by a removal torque comparison with a standard Ti-SLA implant.Clin Oral Implants Res.2012 Oct;23（10）:1210-6. doi: 10.1111/j.1600-0501.2011.02291.x.Epub 2011 Nov 14. 22 Gahlert M, Roehling S, Sprecher CM, Kniha H, Milz S, Bormann K. In vivo performance of zirconia and titanium implants: a histomorphometric study in mini pig maxillae.（ジルコニアインプラントとチタンインプラントの生体パフォーマンス：ミニ豚の上顎の組織形態研究）Clin Oral Implants Res.2012 Mar;23（3）:281-6. doi: 10.1111/j.1600-0501.2011.02157.x.Epub 2011 Aug 2.23 Gahlert M1, Röhling S, Wieland M, Eichhorn S, Küchenhoff H, Kniha H A comparison study of the osseointegration of zirconia and titanium dental implants.A biomechanical evaluation in the maxilla of pigs.Clin Implant Dent Relat Res.2010 Dec;12（4）:297-305. doi: 10.1111/j.1708-8208.2009.00168.x.

ZLA® 23 Roehling S, Astasov-Frauenhoffer M, Hauser-Gerspach, Braissant O, Woelfler H, et a., In Vitro Biofilm Formation On Titanium And Zirconia Implant Surfaces, J Periodontol.2016 Oct 7:1-16.[Epub ahead of print] DOI: 10.1902/jop.2016.160245