mucoderm®
Mastering esthetics.

돼지 3D 콜라겐 이식편

Mucoderm® 은 환자 자신의 결합 조직에 대한 특정 적응증에 진정한 대안을 제공합니다. 돼지 진피로 만든 안정한 3차원 콜라겐 연조직 대체물은 색과 질감을 포함하여 빠른 혈관 재생 및 연조직 통합을 지원합니다.

특장점

안전성 및 생체적합성

특정, 인증된 mucoderm®의 다단계 세척 공정은 모든 비콜라겐 단백질과 세포는 물론 잠재적인 면역원, 박테리아 및 바이러스를 효과적으로 제거합니다. 따라서, mucoderm®은 절대적으로 안전하고 순수한 콜라겐 제1형 및 제3형 기질입니다. mucoderm®은 생체 적합성을 가지며 섬유모세포 및 내피 세포의 접착 및 증식을 지원합니다.


3차원 기질

고유한 다공성 구조의 mucoderm®은 혈관과 세포 내증식에 이상적인 지지체가 되며 빠른 조직 통합과 혈관 재생을 촉진합니다.²,³


높은 인장 강도

구조적 안정성 덕분에 mucoderm®은 다음이 가능합니다.

  • 봉합, 고정 또는 나사 고정
  • 필요한 크기와 모양으로 쉽게 절단
  • 기질을 찢을 위험 없이 터널 기술로 쉽게 적용

사람의 조직과 유사한 구조

mucoderm®은 특정 적응증에서 환자 본인의 조직의 성공 가능한 대안을 제시합니다:

  • 6~9개월 이내에 환자의 조직으로 완전히 재형성됩니다.
  • 환자의 불편함과 공여부 이환을 줄입니다.

youTooth의 mucoderm® 

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References

1 Zirk et al. Prevention of post-operative bleeding in hemostatic compromised patients using native porcine collagen fleeces-retrospective study of a consecutive case series. Oral Maxillofac Surg. 2016. [E-Pub vor Print-Pub] http://www.ncbi.nlm.nih.gov/pubmed/27139018
2 Pabst AM.,  Happe A., Callaway A., Ziebart T., Stratul SI., Ackermann M., Konerding MA., Willershausen B., Kasaj A. In vitro and in vivo characterization of porcine acellular dermal matrix for gingival augmentation. J Periodont Res 2014; Epub 2013 Jul 1.
3 Rothamel D., Benner M., Fienitz T., Happe A., Kreppel M.,  Nickenig HJ. and Zöller JE. Biodegradation pattern and tissue integration of native and cross-linked porcine collagen soft tissue augmentation  matrices – an experimental study in the rat. Head and Face 2014, 10:10.
4 Kasaj A, Levin L, Stratul SI, Götz H, Schlee M, Rütters CB, Konerding MA, Ackermann M, Willershausen B. Pabst AM. The influence of various rehydration protocols on biomechanical properties of different acellular tissue matrices. Clin Oral Ivest. 2015.
5 McGuire MK, et al. A Prospective, Cased-Controlled Study Evaluating the use of Enamel Matrix Derivative on Human Buccal Recession Defects: A Human Histologic Examination. J Periodontol. 2016 Feb 1:1-34.
6 Sculean A, et al. Clinical and histologic evaluation of  human intrabony defects treated with an enamel matrix protein derivative (Emdogain). Int  J  Periodontics Restorative Dent. 2000;20:374–381. 
7 Aspriello SD, et al. Effects of enamel matrix derivative on vascular endothelial growth factor expression and microvessel density in  gingival  tissues  of  periodontal pocket: a comparative study. J Periodontol. 2011 Apr;82(4):606-12.
8 Guimarães et al. Microvessel Density  Evaluation of the Effect of Enamel Matrix Derivative on Soft Tissue After Implant Placement: A Preliminary Study. Int J Periodontics Restorative  Dent. 2015 Sep-Oct;35(5):733-8.
9 Sato et al. Enamel matrix derivative exhibits anti-inflammatory properties in monocytes J Periodontol.  Mar 2008;79(3):535-40
10 Arweiler et al. Antibacterial effect of an enamel matrix protein derivative on in vivo dental biofilm vitality. Clin Oral Investig. 2002 Dec;6(4):205-9. Epub 2002 Nov 14.
11 Maymon-Gil T, et al. Emdogain Promotes Healing of a Surgical Wound in the Rat Oral Mucosa. J. Periodontol. 2016 Jan 16:1-16.
12 Tonetti et al. Enamel matrix proteins in the regenerative therapy of deep intrabony defects – A multicenter, randomized, controlled clinical trial. J Clin Periodontology 2002;29;317-325
13 Tonetti MS et al. Clinical efficacy of periodontal plastic surgery procedures: consensus report of Group 2 of the 10th  European  Workshop  on  Periodontology. J Clin Periodontol. 2014 Apr;41 Suppl 15:S36-43
14 McGuire MK, et al. Evaluation of human recession defects treated with coronally advanced flaps and either enamel matrix derivative  or  connective tissue: comparison of clinical parameters at 10 years. J Periodontol. 2012 Nov;83(11):1353-62
15 Villa O et al. J Periodontol. A Proline-Rich Peptide Mimic Effects of EMD in Rat Oral Mucosal Incisional Wound Healing. 2015 Dec;86(12):1386-95.
16 Jepsen S, et al. A randomized clinical trial comparing enamel matrix derivative and membrane treatment of buccal Class II furcation involvement in mandibular molars. Part I: Study design and results for primary outcomes.J Periodontol. 2004 Aug;75(8):1150-60.
17 According to PUBMED - search term “Emdogain" or "enamel matrix derivative”.
18 Sculean A, et al. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue  regeneration. J  Clin  Periodontol. 2008 Sep;35(9):817-24
19 Almqvist et al. Effects of amelogenins on angiogenesis-asso ciated processes of endothelial cells. J Wound Care. 2011 Feb;20(2):68, 70-5
20 Graziani F, Gennai S, Petrini M, Bettini L, Tonetti M. Enamel matrix derivative stabilizes  blood clot and improves clinical healing in deep pockets after flapless periodontal therapy: A Randomized Clinical Trial. J Clin Periodontol. 2019 Feb; 46(2):231-240.
21 Aimetti M, Ferrarotti F, Mariani GM, Romano F. A novel flapless approach versus minimally invasive surgery in periodontal regeneration with enamel matrix de rivative proteins: a 24-month randomized controlled clinical trial. Clin Oral Investig. 2017 Jan;21(1): 327-337.
22 Straumann Sponsored Study, data on file, study ongoing
23 Wennström JL, Lindhe J. Some effects of enamel matrix proteins on wound healing in the dento-gingival re gion. J Clin Periodontol. 2002 Jan;29(1):9-14