How does Emdogain® promote tissue regeneration?

Emdogain® mimics the processes that take place during tooth development. The amelogenins support the formation of new cell-free cement. The protein matrix in enamel matrix derivatives, i.e., EMD, mimics the natural environment of the developing tissue which naturally stimulates cell differentiation and cell maturation as well as tissue regeneration. ^2-5

Pictures courtesy of Prof. Eiji Funakoshi, Japan

Antibacterial and accelerating fibroblast adhesion

In the first phase of wound healing, Emdogain® has an antibacterial effect and accelerates fibroblast adhesion to the root surface. The various proteins combine to form a matrix that mediates the formation of root cement during natural tooth development. A new periodontal attachment is created and the bone defect regenerates in the months and years that follow. This ‘biological maturation’ continues for up to three years. For this reason, a radiological result can be expected after at least eight months at the earliest.^2-5 Prof. Dr. Anton Sculean is renowned for demonstrating the cellular effects of Emdogain® on humans. In a first study by Sculean on the mode of action, six months postoperatively, newly formed tissue such as cement with collagen fibers and in most cases also bone were observed histologically.^6-9

Angiogenic effect

Emdogain® is a proven preparation with an angiogenic effect that reduces the tendency to bleed and signs of inflammation, promotes the accumulation of cells, the remodeling, consolidation and proliferation of tissue and induces bone healing deep in the defect during wound healing.^10-12 Treatment with Emdogain® achieves a higher clinical gain in attachment and a more effective reduction in probing depth than open debridement alone.^{13, 14}

Pictures courtesy of Prof. Carlos Nemcovsky (Israel)

Lasting success and stable long-term results

Emdogain® more effectively reduces horizontal defect depth in buccal grade II furcation defects on mandibular molars than barrier membranes.¹⁵ Emdogain® also achieves better root coverage in combination with coronally advanced flap (CAF), compared to CAF alone.^{16, 17} Histological studies show that Straumann® Emdogain® supports the formation of new periodontal tissue and a new periodontal attachment in conjunction with a coronally advanced flaps.¹⁸ The success is lasting and, based on the osseous defect filling¹⁹ as well as the root coverage, the use of Emdogain® leads to documented stable 10-year results.²⁰

Pictures courtesy of Prof. Zucchelli (Italy)