cerabone® plus
Mastering application comfort. Sticky bone out of the blister.

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cerabone® plus is a combination of the established bovine bone grafting material cerabone® and sodium hyaluronate. Upon contact with saline or blood, it forms a a sticky bone material, leading to excellent handling comfort by allowing both easy uptake and delivery to the site of application.

Features and benefits

Sticky and malleable after hydration

Thanks to the pronounced liquid binding capacities of hyaluronate, cerabone® plus, upon hydration, forms a connected and malleable mass that provides easier application compared to conventional particulate bone grafts. cerabone® plus allows easy uptake, precise particle application, efficient defect filling and easy defect contouring.
Ideal liquid binding capacity of hyaluronic acid

Hyaluronic acid is capable to incorporate a liquid volume 1000 times larger than the molecule itself. It is highly hygroscopic, biodegradable, and will be quickly decomposed in the early phase of healing.
Human-like bone structure of bone mineral component

The bone mineral component (cerabone®) displays human-like bone structure with three-dimensional pore-network and rough surface. The osteoconductive scaffold promotes the adhesion and invasion of bone forming cells, resulting in complete integration of the granules into newly formed bone matrix.
1200 °C safety and biocompatibility

Utilizing heat and water only, the 1200 °C heating process of cerabone® removes all organic component and leads to a pure natural bone mineral. Gamma-irradiation ensures final sterility of cerabone® plus.
Long-term volume stability

With limited degradation, cerabone® plus provides predictable and viable structural support to the augmented site, which is particularly advantageous for support of the soft tissue in the aesthetic region, for preservation of the ridge shape and to protect autologous or allogenic bone from resorption.
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*Cerabone® plus is now available in Switzerland, Germany, Nordics and Chile.

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References

1. Pröhl A et al. 2021. In Vivo Analysis of the Biocompatibility and Bone Healing Capacity of a Novel Bone Grafting Material Combined with Hyaluronic Acid. Int J Mol Sci. May 1;22(9):48.
2. cerabone® plus usability test, data on file.
3. Customer survey cerabone® plus including 156 clinicians, data on file.
4. Tadic and Epple 2004. A thorough physicochemical characterisation of 14 calcium phosphate-based bone substitution materials in compari­son to natural bone. Biomaterials. 25(6):987-94.
5. Seidel and Dingeldein 2004. cerabone® – Bovine Based Spongiosa Ceramic Seidel et al. Mat.-wiss. u. Werkstofftech. 35:208–212
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11. Riachi et al. 2012. Influence of material properties on rate of resorption of two bone graft materials af-ter sinus lift using radiographic assessment. Int J Dent. 2012:737262.
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13. Fienitz et al. 2016. Histological and radiological evaluation of sintered and non-sintered deproteinized bovine bone substitute materials in sinus augmentation procedures. A prospective, randomized-con-trolled, clinical multicenter study. Clin Oral Investig. 21(3):787-794.
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15. John et al. 2009 Perspectives in the selection of hyaluronic acid fillers for facial wrinkles and aging skin. Patient Prefer Adherence. Nov 3;3:225-30.
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17. Kyyak et al. 2021 The Influence of Hyaluronic Acid Biofunctionalization of a Bovine Bone Substitute on Osteoblast Activity In Vitro. Materials (Basel). 2021 May 27;14(11):2885.
18. Rothamel et al. 2012. Biocompatibility and biodegradation of a native porcine pericardium membrane: results of in vitro and in vivo examinations. Int J Oral Maxillofac Implants.27(1):146-54. 19. Brown et al. 2000. New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication. Proc Natl Acad Sci U S A. 28;97(7):3418-21.
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22. cerabone® usability test, data on file.
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